Research output per year
Research output per year
Personal profile
Overview
I am a physiologist with an interest in placental barrier transfer, blood flow regulation and toxicology. My expertise includes transplacental solute and water transfer; transcellular and paracellular routes; and the regulation of fetoplacental vascular tone, and its dysregulation in disease. I have interdisciplinary collaborations with: (i) industry, mathematicians, pharmacologists, clinicians, bioengineers and material scientists. Key areas of study include: how pregnancy diseases impact placental function, placental pathology and stillbirth risk; pharmaco- and chemicodynamics; placental toxicology; and the use of human placentas in New Alternative Methods (NAMs)for toxicology testing, in line with 3Rs directives.
I have formed and co-lead an international consortium (PlaNet) of industrialists, placental physiologists, clinicians, and mathematicians from numerous international centres to promote ex vivo perfusion of the human placenta towards validation for acceptance as a NAM method by the food, drug and chemical regulators.
Research interests
- Transplacental paracellular pathways
- Regulation of fetoplacental blood flow
- Regulation of placental oxygen transfer
- Regulation of transplacental water and solute transfer
- Signalling in the fetoplacental endothelium
- Placental Toxicology
- Supervisor of 4 PhD students
Teaching
Senior Academic Advisor, and Advanced Personal Excellence Pathway Supervisor on the Bachelor of Medicine, Bachelor of Surgery program (MBChB)
Project Supervisor for MSc courses in Reproduction & Pregnancy, Precision Medicine and Clinical Biochemistry.
Health & Safety module teacher, for MSc Reproduction & Medicine course
My collaborations
External
Dr Tony Shock, Dr Joe Rastrick & Dr Alsion Wolfreys, UCB Biopharma
Dr Nicola Powles-Glover, ExxonMobil
Dr Rhiannon David & Dr Jayne Harris, AstraZenecca
Dr Sarah Jones & Dr Sarah Arrowsmith, Manchester Metroplolitan University
Prof Claire Meek & Dr Laura Kusinski, University of Leicester
Prof Stefan Hansson, University of Lund, Sweden
Dr Adam Brook, York & Scarborough NHS Teaching Hospitals
Prof. Rohan Lewis, University of Southampton, UK.
Ass Prof Gowsihan Poologasundarampillai, University fo Birmingham, UK
Dr Michelle Durrows, Roslaind Franklin Institute, Harwell, UK
Prof Peter Lee, UCL
Prof Christian Wadsack, Medical University of Graz, Austria.
Prof Jan Danser, Erasmus University, The Netherlands
Dr Rick Geupink, Radboud University, The Netherlands
Dr Paola Mian, Groningen University, The Netherlands
Prof Christiane Albrecht, Bern University, Switzerland
Dr Tina Buerki, EMPA Swiss Federal Laboratories, Switzerland
Dr Line Mathiesen, University of Copenhagen, Denmark
Prof Udo Markert, University of Jena, Germany
Dr Sophie Preuss, University of Lubeck, Germany
Dr Niels Rochow, Paracelsus University, Germany
Memberships of committees and professional bodies
Physiological Society
European Teratology Society
HESI-DART, Washington
European Placenta Group
International Federation of Placenta Associations
Blair Bell Research Society (Royal College of Obstetricians & Gynaecologists)
NC3Rs non-animal testing (NATs) specialist interest group
Methodological knowledge
Human placenta ex vivo dual and IVS perfusion systems
Human placenta-on-a-chip technology
Placental endothelial cell physiology
Endothelial cell-flow shear-stress investigation
Phosphoproteome analysis
ELISAs and other assays
Qualifications
BSc(HONS), MPhil, PhD
Social responsibility
Maternal and Fetal Health Research Centre Patient Research Involvement Group
Tommy's charity events
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, REGULATION OF FETOPLACENTAL VASCULAR TONE AND TRANSPLACENTAL TRANSFER, The University of Manchester
Award Date: 1 Dec 2007
Master of Philosophy, Permeability of the Human Placenta, The University of Manchester
Award Date: 1 Dec 2001
Bachelor of Science, Applied Biological Sciences, Manchester Metropolitan University (MMU)
Award Date: 1 Jul 1988
Areas of expertise
- RG Gynecology and obstetrics
- Placenta
- Physiology
- Toxicology
- Endocrinology
- Pathology
Research Beacons, Institutes and Platforms
- Biotechnology
- Lydia Becker Institute
- Christabel Pankhurst Institute
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Author Reply: Free Foetal Haemoglobin in Severe Early-Onset Foetal Growth Restriction: A Prospective Multi-Centre Study
Brook, A., Baynes, G. C., Scargill, J., Evangelinos, A., Brennan-Richardson, C., Dow, F., Ginsberg, Y., Weissbach, T., Brodszki, J., Hansson, E., Diemert, A., Hecher, K., Maksym, K., Marlow, N., Spencer, R. N., David, A. L., Hansson, S. R. & Brownbill, P., 16 Jul 2025, (E-pub ahead of print) In: BJOG: An International Journal of Obstetrics & Gynaecology.Research output: Contribution to journal › Letter › peer-review
Open AccessFile2 Downloads (Pure) -
Free Foetal Haemoglobin in Severe Early-Onset Foetal Growth Restriction: A Prospective Multi-Centre Study
Brook, A., Baynes, G., Scargill, J., Evangelinos, A., Brennan-Richardson, C., Dow, F., Ginsberg, Y., Weissbach, T., Brodszki, J., Hansson, E., Diemert, A., Hecher, K., Maksym, K., Marlow, N., Spencer, R. N., David, A. L., Hansson, S. R. & Brownbill, P., 2025, In: BJOG.Research output: Contribution to journal › Letter › peer-review
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Development of integrated models of the fetal and placental circulations to improve prediction of stillbirth.
Clark, A., Jackson, T., Nagahawatte, N., Poologasundarampillai, G., Brownbill, P., Evangelinos, A., Pennington, A., Darrow, M., Van Loon, R., Chernyavsky, I., Heazell, A. & James, J., 2 Sept 2024, p. e46. 1 p.Research output: Contribution to conference › Abstract › peer-review
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Fetoplacental vascular effects of maternal adrenergic antihypertensive and cardioprotective medications in pregnancy
Tropea, T., Mavichak, W., Evangelinos, A., Brennan-Richardson, C., Cottrell, E., Myers, J., Johnstone, E. & Brownbill, P., 1 Nov 2023, In: J Hypertens. 41, 11, p. 1675-1687 13 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Ex vivo perfusion of the human placenta to investigate pregnancy pathologies
Zabela, R., Favaroa, R., Grotena, T., Brownbill, P. & Jones, S., 2022, In: Placenta. 130, p. 1 8 p.Research output: Contribution to journal › Review article › peer-review
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Maternal & Fetal Health Research Centre
Stevens, A. (PI), Heazell, A. (PI), Tower, C. (PI), Brison, D. (PI), Johnstone, E. (PI), Cottrell, E. (PI), Mann, E. (PI), Ingram, E. (PI), Crocker, I. (PI), Chernyavsky, I. (PI), Myers, J. (PI), Aplin, J. (PI), Higgins, L. (PI), Harris, L. (PI), Dilworth, M. (PI), Westwood, M. (PI), Whitworth, M. (PI), Desforges, M. (PI), Brownbill, P. (PI), Ruane, P. (PI), Sturmey, R. (PI), Worton, S. (PI), Greenwood, S. (PI), Sibley, C. (PI), Belchamber, K. (PI), Palin, V. (PI), Povey, A. (PI), Ormesher, L. (PI) & Perchard, R. (PI)
1/09/18 → 31/12/35
Project: Research
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Tommy's 2024-2025 Annual Budget
Heazell, A. (PI), Aplin, J. (CoI), Brownbill, P. (CoI), Cottrell, E. (CoI), Desforges, M. (CoI), Dilworth, M. (CoI), Higgins, L. (CoI), Johnstone, E. (CoI), Myers, J. (CoI), Palin, V. (CoI), Ruane, P. (CoI), Stevens, A. (CoI), Tropea, T. (CoI), Westwood, M. (CoI) & Worton, S. (CoI)
1/04/24 → 31/03/25
Project: Research
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Multi-modal studies to understand pregnancy and prevent stillbirth
Heazell, A. (PI), Brownbill, P. (CoI), Chernyavsky, I. (CoI), Cotter, S. (CoI), Duhig, K. (CoI), Higgins, L. (CoI), Jensen, O. (CoI), Johnstone, E. (CoI) & Whitfield, C. (CoI)
17/10/22 → 31/03/25
Project: Research
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Does maternal ambient air exposure to traffic-related particulate matter induce carcinogenic responses in the foetus?
Brownbill, P. (PI)
1/01/20 → 31/12/22
Project: Research
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Evaluation of the Safety of Maternal Anti-hypertensive Medicines on Placental Vascular Function.
Brownbill, P. (PI), Cottrell, E. (CoI), Johnstone, E. (CoI), Myers, J. (CoI) & Tropea, T. (Grant contributor)
1/11/19 → 31/10/22
Project: Research
Activities
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Placenta (Journal)
Brownbill, P. (Member of editorial board)
7 Jan 2020 → …Activity: Publication peer-review and editorial work › Editorial work › Research
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The human placenta – the transfer interface between mum and baby
Brownbill, P. (Speaker)
3 Apr 2019Activity: Talk or presentation › Invited talk › Research
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European Commission (External organisation)
Brownbill, P. (Academic expert member)
Feb 2019 → Apr 2019Activity: Membership › Membership of committee › Research
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Medical University of Graz
Brownbill, P. (Honorary)
18 Dec 2018 → …Activity: External visiting positions or secondments › Visiting an external academic institution › Research
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European Commission (External organisation)
Brownbill, P. (Academic expert member)
Feb 2018 → Apr 2018Activity: Membership › Membership of committee › Research
Datasets
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Quantitative assessment of placental morphology may identify specific causes of stillbirth
Ptacek, I. (Contributor), Smith, A. (Contributor), Garrod, A. (Contributor), Bullough, S. (Contributor), Bradley, N. (Contributor), Batra, G. (Contributor), Sibley, C. (Contributor), Jones, R. (Contributor), Brownbill, P. (Contributor) & Heazell, A. (Contributor), figshare , 6 Feb 2016
DOI: 10.6084/m9.figshare.c.3622058.v1, https://figshare.com/collections/Quantitative_assessment_of_placental_morphology_may_identify_specific_causes_of_stillbirth/3622058/1
Dataset
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Research data for a study on haemoglobin and heme defences - "EVERREST" study
Brook, A. (Creator), Baynes, G. (Creator), Scargill, J. (Creator), Evangelinos, A. (Creator), Brennan-Richardson, C. (Creator), Dow, F. (Creator), Ginsberg, Y. (Creator), Weissbach, T. (Creator), Brodszki, J. (Creator), Hansson, E. (Creator), Diemert, A. (Creator), Hetcher, K. (Creator), Maksym, K. (Creator), Marlow, N. (Creator), Spencer, R. (Creator), David, A. (Creator), Hansson, S. R. (Creator) & Brownbill, P. (Creator), University of Manchester Figshare, 10 Jun 2024
DOI: 10.48420/25924327, https://figshare.manchester.ac.uk/articles/dataset/Research_data_for_a_study_on_haemoglobin_and_heme_defences_-_EVERREST_study/25924327
Dataset
Press/Media
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Vital research carried out in our city is helping Greater Manchester mums get through a difficult pregnancy - here are their stories
18/09/19
1 Media contribution
Press/Media: Research
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Scientists discover a major cause of premature birth – as well as a promising treatment
10/06/18
1 item of Media coverage
Press/Media: Research
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iNEWS: Scientists discover a major cause of premature birth – as well as a promising treatment
10/06/18
1 item of Media coverage
Press/Media: Research
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Texas - Manchester research collaboration & "EU PlaNet" network co-ordination
9/03/16
1 item of Media coverage
Press/Media: Research