Controversies in the diagnosis and management of preterm prelabour rupture of the membranes

Megan Hall; Megan Sharps; Lily Wright; Adam Stevens; Andrew Shennan; Lisa Story

doi:10.1016/j.ejogrb.2025.114635

Controversies in the diagnosis and management of preterm prelabour rupture of the membranes

Megan Hall, Megan Sharps, Lily Wright, Adam Stevens, Andrew Shennan, Lisa Story

Division of Developmental Biology & Medicine (L5)

King's College London

Research output: Contribution to journal › Article › peer-review

Abstract

Preterm prelabour rupture of the membranes precedes around 30% of spontaneous preterm births. As well as its associations with complications of prematurity, it is additionally associated with pulmonary hypoplasia as well as increased rates of maternal sepsis and its sequelae. However, all stages of clinical management remain a challenge: from diagnosis, through to management and timing of delivery. This review discusses some of the major challenges clinicians face when caring for women with preterm prelabour rupture of the membranes.

Original language	English
Pages (from-to)	114635
Journal	European journal of obstetrics, gynecology, and reproductive biology
Volume	313
DOIs	https://doi.org/10.1016/j.ejogrb.2025.114635
Publication status	E-pub ahead of print - 7 Aug 2025

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10.1016/j.ejogrb.2025.114635

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title = "Controversies in the diagnosis and management of preterm prelabour rupture of the membranes",

abstract = "Preterm prelabour rupture of the membranes precedes around 30\% of spontaneous preterm births. As well as its associations with complications of prematurity, it is additionally associated with pulmonary hypoplasia as well as increased rates of maternal sepsis and its sequelae. However, all stages of clinical management remain a challenge: from diagnosis, through to management and timing of delivery. This review discusses some of the major challenges clinicians face when caring for women with preterm prelabour rupture of the membranes.",

author = "Megan Hall and Megan Sharps and Lily Wright and Adam Stevens and Andrew Shennan and Lisa Story",

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AU - Wright, Lily

AU - Stevens, Adam

AU - Shennan, Andrew

AU - Story, Lisa

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AB - Preterm prelabour rupture of the membranes precedes around 30% of spontaneous preterm births. As well as its associations with complications of prematurity, it is additionally associated with pulmonary hypoplasia as well as increased rates of maternal sepsis and its sequelae. However, all stages of clinical management remain a challenge: from diagnosis, through to management and timing of delivery. This review discusses some of the major challenges clinicians face when caring for women with preterm prelabour rupture of the membranes.

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SN - 0301-2115

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JO - European journal of obstetrics, gynecology, and reproductive biology

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ER -

Controversies in the diagnosis and management of preterm prelabour rupture of the membranes

Abstract

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