Human atrial fibrillation and genetic defects in transient outward currents: mechanistic insights from multi-scale computational models

Biochemistry, Genetics and Molecular Biology

• Atrial Fibrillation 100%
• Heart Excitation 100%
• Effective Refractory Period 100%
• Wild Type 50%
• Dispersion 50%
• Repolarization 50%
• KCND2 50%
• KCND3 50%
• Lifespan 50%
• Tissue Level 50%
• Induced Mutation 50%
• Membrane Potential 50%
• Action Potential Duration 50%
• Gain of Function Mutation 50%