Micro RNA-411 Expression Improves Cardiac Phenotype Following Myocardial Infarction in Mice

Ardiansah Bayu Nugroho; Nicholas Stafford; Min Zi; Sukhpal Prehar; Ryan Potter; Dowan Kwon; Yulia Suciati Kohar; Efta Triastuti; Thuy Anh Bui; Elizabeth J Cartwright; Delvac Oceandy

doi:10.1016/j.jacbts.2022.05.008

Micro RNA-411 Expression Improves Cardiac Phenotype Following Myocardial Infarction in Mice

Ardiansah Bayu Nugroho, Nicholas Stafford, Min Zi, Sukhpal Prehar, Ryan Potter, Dowan Kwon, Yulia Suciati Kohar, Efta Triastuti, Thuy Anh Bui, Elizabeth J Cartwright, Delvac Oceandy

Manchester Metropolitan University (MMU)

Research output: Contribution to journal › Article › peer-review

Abstract

Induction of endogenous regenerative capacity has emerged as one promising approach to repair damaged hearts following myocardial infarction (MI). Re-expression of factors that are exclusively expressed during embryonic development may reactivate the ability of adult cardiomyocytes to regenerate. Here, we identified miR-411 as a potent inducer of cardiomyocyte proliferation. Overexpression of miR-411 in the heart significantly increased cardiomyocyte proliferation and survival in a model MI. We found that miR-411 enhances the activity of YAP, the main downstream effector of the Hippo pathway, in cardiomyocytes. In conclusion, miR-411 induces cardiomyocyte regeneration and improves cardiac function post-MI likely by modulating the Hippo/YAP pathway.

Original language	English
Pages (from-to)	859-875
Number of pages	17
Journal	JACC: Basic to Translational Science
Volume	7
Issue number	9
DOIs	https://doi.org/10.1016/j.jacbts.2022.05.008
Publication status	Published - Sept 2022

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10.1016/j.jacbts.2022.05.008

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title = "Micro RNA-411 Expression Improves Cardiac Phenotype Following Myocardial Infarction in Mice",

abstract = "Induction of endogenous regenerative capacity has emerged as one promising approach to repair damaged hearts following myocardial infarction (MI). Re-expression of factors that are exclusively expressed during embryonic development may reactivate the ability of adult cardiomyocytes to regenerate. Here, we identified miR-411 as a potent inducer of cardiomyocyte proliferation. Overexpression of miR-411 in the heart significantly increased cardiomyocyte proliferation and survival in a model MI. We found that miR-411 enhances the activity of YAP, the main downstream effector of the Hippo pathway, in cardiomyocytes. In conclusion, miR-411 induces cardiomyocyte regeneration and improves cardiac function post-MI likely by modulating the Hippo/YAP pathway.",

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year = "2022",

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doi = "10.1016/j.jacbts.2022.05.008",

language = "English",

volume = "7",

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TY - JOUR

T1 - Micro RNA-411 Expression Improves Cardiac Phenotype Following Myocardial Infarction in Mice

AU - Nugroho, Ardiansah Bayu

AU - Stafford, Nicholas

AU - Zi, Min

AU - Prehar, Sukhpal

AU - Potter, Ryan

AU - Kwon, Dowan

AU - Kohar, Yulia Suciati

AU - Triastuti, Efta

AU - Bui, Thuy Anh

AU - Cartwright, Elizabeth J

AU - Oceandy, Delvac

PY - 2022/9

Y1 - 2022/9

N2 - Induction of endogenous regenerative capacity has emerged as one promising approach to repair damaged hearts following myocardial infarction (MI). Re-expression of factors that are exclusively expressed during embryonic development may reactivate the ability of adult cardiomyocytes to regenerate. Here, we identified miR-411 as a potent inducer of cardiomyocyte proliferation. Overexpression of miR-411 in the heart significantly increased cardiomyocyte proliferation and survival in a model MI. We found that miR-411 enhances the activity of YAP, the main downstream effector of the Hippo pathway, in cardiomyocytes. In conclusion, miR-411 induces cardiomyocyte regeneration and improves cardiac function post-MI likely by modulating the Hippo/YAP pathway.

AB - Induction of endogenous regenerative capacity has emerged as one promising approach to repair damaged hearts following myocardial infarction (MI). Re-expression of factors that are exclusively expressed during embryonic development may reactivate the ability of adult cardiomyocytes to regenerate. Here, we identified miR-411 as a potent inducer of cardiomyocyte proliferation. Overexpression of miR-411 in the heart significantly increased cardiomyocyte proliferation and survival in a model MI. We found that miR-411 enhances the activity of YAP, the main downstream effector of the Hippo pathway, in cardiomyocytes. In conclusion, miR-411 induces cardiomyocyte regeneration and improves cardiac function post-MI likely by modulating the Hippo/YAP pathway.

U2 - 10.1016/j.jacbts.2022.05.008

DO - 10.1016/j.jacbts.2022.05.008

M3 - Article

C2 - 36317138

SN - 2452-302X

VL - 7

SP - 859

EP - 875

JO - JACC: Basic to Translational Science

JF - JACC: Basic to Translational Science

IS - 9

ER -

Micro RNA-411 Expression Improves Cardiac Phenotype Following Myocardial Infarction in Mice

Abstract

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