Photosensitizer and anticancer drug-loaded 2D nanosheet: Preparation, stability and anticancer property

Gang Liu; Ping Zhao; Neng Liu; Fumi Yoshino; Hongmei Qin; Yajuan Zou; Shengwei Shi; Tsukuru Amano; Jose Aguilar Cosme; Yasunobu Nagano; Hitoshi Tamiaki; Naoki Komatsu

doi:10.1088/2053-1583/ab377b

Photosensitizer and anticancer drug-loaded 2D nanosheet: Preparation, stability and anticancer property

Gang Liu, Ping Zhao, Neng Liu, Fumi Yoshino, Hongmei Qin, Yajuan Zou, Shengwei Shi, Tsukuru Amano, Jose Aguilar Cosme, Yasunobu Nagano, Hitoshi Tamiaki, Naoki Komatsu

Materials Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

Cancer phototherapy (PT) including photodynamic therapy (PDT) and photothermal therapy (PTT) has attracted extensive interest due to its non-invasive and region-specific nature. In order to enhance the efficacy, we have fabricated various nanocomposites consisting of a photosensitizer (chlorin e6 (Ce6), pheophorbide a (Pa) or bacteriopheophorbide a (bPa)) for PDT and a two-dimensional nanosheet (graphene or MoS2) for PTT by a one-pot protocol through liquid phase exfoliation. In addition, an anticancer drug (doxorubicin (DOX) or irinotecan (Ir)) was loaded on the nanosheet in the same way for comparison. The nanocomposites demonstrated stability when dispersed in water except for MoS2–Ir. We observed that MoS2-Ce6 killed cancer cells over ten times more effectively than other Ce6-loaded nanocomposites.

Original language	English
Article number	045035
Pages (from-to)	1-13
Number of pages	13
Journal	2D Materials
Volume	6
DOIs	https://doi.org/10.1088/2053-1583/ab377b
Publication status	Published - 3 Sept 2019

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@article{29b46f7fd7d84039893dee5dce742f97,

title = "Photosensitizer and anticancer drug-loaded 2D nanosheet: Preparation, stability and anticancer property",

abstract = "Cancer phototherapy (PT) including photodynamic therapy (PDT) and photothermal therapy (PTT) has attracted extensive interest due to its non-invasive and region-specific nature. In order to enhance the efficacy, we have fabricated various nanocomposites consisting of a photosensitizer (chlorin e6 (Ce6), pheophorbide a (Pa) or bacteriopheophorbide a (bPa)) for PDT and a two-dimensional nanosheet (graphene or MoS2) for PTT by a one-pot protocol through liquid phase exfoliation. In addition, an anticancer drug (doxorubicin (DOX) or irinotecan (Ir)) was loaded on the nanosheet in the same way for comparison. The nanocomposites demonstrated stability when dispersed in water except for MoS2–Ir. We observed that MoS2-Ce6 killed cancer cells over ten times more effectively than other Ce6-loaded nanocomposites.",

author = "Gang Liu and Ping Zhao and Neng Liu and Fumi Yoshino and Hongmei Qin and Yajuan Zou and Shengwei Shi and Tsukuru Amano and \{Aguilar Cosme\}, Jose and Yasunobu Nagano and Hitoshi Tamiaki and Naoki Komatsu",

year = "2019",

month = sep,

day = "3",

doi = "10.1088/2053-1583/ab377b",

language = "English",

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TY - JOUR

T1 - Photosensitizer and anticancer drug-loaded 2D nanosheet

T2 - Preparation, stability and anticancer property

AU - Liu, Gang

AU - Zhao, Ping

AU - Liu, Neng

AU - Yoshino, Fumi

AU - Qin, Hongmei

AU - Zou, Yajuan

AU - Shi, Shengwei

AU - Amano, Tsukuru

AU - Aguilar Cosme, Jose

AU - Nagano, Yasunobu

AU - Tamiaki, Hitoshi

AU - Komatsu, Naoki

PY - 2019/9/3

Y1 - 2019/9/3

N2 - Cancer phototherapy (PT) including photodynamic therapy (PDT) and photothermal therapy (PTT) has attracted extensive interest due to its non-invasive and region-specific nature. In order to enhance the efficacy, we have fabricated various nanocomposites consisting of a photosensitizer (chlorin e6 (Ce6), pheophorbide a (Pa) or bacteriopheophorbide a (bPa)) for PDT and a two-dimensional nanosheet (graphene or MoS2) for PTT by a one-pot protocol through liquid phase exfoliation. In addition, an anticancer drug (doxorubicin (DOX) or irinotecan (Ir)) was loaded on the nanosheet in the same way for comparison. The nanocomposites demonstrated stability when dispersed in water except for MoS2–Ir. We observed that MoS2-Ce6 killed cancer cells over ten times more effectively than other Ce6-loaded nanocomposites.

AB - Cancer phototherapy (PT) including photodynamic therapy (PDT) and photothermal therapy (PTT) has attracted extensive interest due to its non-invasive and region-specific nature. In order to enhance the efficacy, we have fabricated various nanocomposites consisting of a photosensitizer (chlorin e6 (Ce6), pheophorbide a (Pa) or bacteriopheophorbide a (bPa)) for PDT and a two-dimensional nanosheet (graphene or MoS2) for PTT by a one-pot protocol through liquid phase exfoliation. In addition, an anticancer drug (doxorubicin (DOX) or irinotecan (Ir)) was loaded on the nanosheet in the same way for comparison. The nanocomposites demonstrated stability when dispersed in water except for MoS2–Ir. We observed that MoS2-Ce6 killed cancer cells over ten times more effectively than other Ce6-loaded nanocomposites.

U2 - 10.1088/2053-1583/ab377b

DO - 10.1088/2053-1583/ab377b

M3 - Article

SN - 2053-1583

VL - 6

SP - 1

EP - 13

JO - 2D Materials

JF - 2D Materials

M1 - 045035

ER -

Photosensitizer and anticancer drug-loaded 2D nanosheet: Preparation, stability and anticancer property

Abstract

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