The effect on treatment response of fibromyalgic symptoms in early rheumatoid arthritis patients: results from the ESPOIR cohort.

Josefina Durán; Bernard Combe; Jingbo Niu; Nathalie Rincheval; Cécile Gaujoux-Viala; David T Felson

doi:10.1093/rheumatology/kev254

The effect on treatment response of fibromyalgic symptoms in early rheumatoid arthritis patients: results from the ESPOIR cohort.

Josefina Durán, Bernard Combe, Jingbo Niu, Nathalie Rincheval, Cécile Gaujoux-Viala, David T Felson

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: To evaluate whether patients with RA who belong to the spectrum of fibromyalgic RA (FRA) have an impaired response to treatment measured by traditional activity scores. METHODS: Patients from the ESPOIR cohort were analysed. This prospective cohort included 813 patients with early arthritis not initially receiving DMARDs. Among the 697 patients who met RA classification criteria, we studied two groups, one with and the other without FRA. The following endpoints were compared at 6, 12 and 18 months using a mixed linear regression model: 28-joint DAS (DAS28), Simple Disease Activity Index (SDAI), Clinical Disease Activity Index (CDAI) and HAQ. In addition, attainment of low disease activity (LDA; DAS28

Original language	English
Pages (from-to)	2166-2170
Number of pages	4
Journal	Rheumatology (Oxford, England)
Volume	54
Issue number	12
DOIs	https://doi.org/10.1093/rheumatology/kev254
Publication status	Published - 2015

Keywords

DMARDs
disease activity scores
early rheumatoid arthritis
fibromyalgia
fibromyalgic RA
outcome measures
rheumatoid arthritis
therapy
treat to target

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10.1093/rheumatology/kev254

Arthritis Research UK Centre of Excellence in Epidemiology.
Symmons, D. (PI), Bruce, I. (CoI), Dixon, W. (CoI), Felson, D. (CoI), Hyrich, K. (CoI), Lunt, M. (CoI), Mcbeth, J. (CoI), O'Neill, T. (CoI) & Verstappen, S. (CoI)
1/08/13 → 31/07/18
Project: Research

Cite this

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title = "The effect on treatment response of fibromyalgic symptoms in early rheumatoid arthritis patients: results from the ESPOIR cohort.",

abstract = "OBJECTIVE: To evaluate whether patients with RA who belong to the spectrum of fibromyalgic RA (FRA) have an impaired response to treatment measured by traditional activity scores. METHODS: Patients from the ESPOIR cohort were analysed. This prospective cohort included 813 patients with early arthritis not initially receiving DMARDs. Among the 697 patients who met RA classification criteria, we studied two groups, one with and the other without FRA. The following endpoints were compared at 6, 12 and 18 months using a mixed linear regression model: 28-joint DAS (DAS28), Simple Disease Activity Index (SDAI), Clinical Disease Activity Index (CDAI) and HAQ. In addition, attainment of low disease activity (LDA; DAS28",

keywords = "DMARDs, disease activity scores, early rheumatoid arthritis, fibromyalgia, fibromyalgic RA, outcome measures, rheumatoid arthritis, therapy, treat to target",

author = "Josefina Dur{\'a}n and Bernard Combe and Jingbo Niu and Nathalie Rincheval and C{\'e}cile Gaujoux-Viala and Felson, \{David T\}",

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doi = "10.1093/rheumatology/kev254",

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AU - Durán, Josefina

AU - Combe, Bernard

AU - Niu, Jingbo

AU - Rincheval, Nathalie

AU - Gaujoux-Viala, Cécile

AU - Felson, David T

PY - 2015

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N2 - OBJECTIVE: To evaluate whether patients with RA who belong to the spectrum of fibromyalgic RA (FRA) have an impaired response to treatment measured by traditional activity scores. METHODS: Patients from the ESPOIR cohort were analysed. This prospective cohort included 813 patients with early arthritis not initially receiving DMARDs. Among the 697 patients who met RA classification criteria, we studied two groups, one with and the other without FRA. The following endpoints were compared at 6, 12 and 18 months using a mixed linear regression model: 28-joint DAS (DAS28), Simple Disease Activity Index (SDAI), Clinical Disease Activity Index (CDAI) and HAQ. In addition, attainment of low disease activity (LDA; DAS28

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KW - DMARDs

KW - disease activity scores

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KW - fibromyalgia

KW - fibromyalgic RA

KW - outcome measures

KW - rheumatoid arthritis

KW - therapy

KW - treat to target

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DO - 10.1093/rheumatology/kev254

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JO - Rheumatology (Oxford, England)

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The effect on treatment response of fibromyalgic symptoms in early rheumatoid arthritis patients: results from the ESPOIR cohort.

Abstract

Keywords

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Projects

Arthritis Research UK Centre of Excellence in Epidemiology.

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