ADVANCED CARDIAC IMAGING IN LEFT VENTRICULAR HYPERTROPHY

Abstract

Left ventricular hypertrophy (LVH) is a common finding in daily clinical practice, with a multitude of different causes. Irrespective of the underlying cause, LVH conveys independent adverse prognostic implications, even in the face of adequate treatment of the underlying cause. The complexity in understanding how it develops on a molecular level partly explains why no treatment exists for left ventricular hypertrophy as a disease entity in its own right, and in addition, translating bench to bedside, i.e. observing any molecular and subsequent clinical therapeutic effect of novel therapy can prove difficult. Advanced cardiac imaging techniques have revolutionised our understanding of the natural history of cardiac diseases. However, the next step is creating a link between basic science and advanced imaging, including structural, functional and metabolic assessment, with tissue characterisation, thereby providing an avenue for either identifying therapeutic targets or assessing the effect of novel therapy, using changes seen on imaging as markers for molecular activity. This work aims to explore such links, in three causes of left ventricular hypertrophy: Anderson-Fabry disease, aortic stenosis and hypertrophic cardiomyopathy, using echocardiography, magnetic resonance imaging, and magnetic resonance spectroscopy.

Date of Award	23 Jul 2018
Original language	English
Awarding Institution	The University of Manchester
Supervisor	Christopher Miller (Supervisor), Simon Ray (Supervisor) & Matthias Schmitt (Supervisor)