Research output per year
Research output per year
Equipments Details
Description
The Mass Spectrometry & Separations Facility (MS&SEP) is a core facility supporting research and teaching across the Faculty of Science and Engineering. In addition we support research from wider UoM researchers from the Faculty of Biology, Medicine & Health. We also support external collaborations and provide analytical services to external customers. We are a team of 13 research technical professionals and are sited across two sites; the Manchester Institute of Biotechnology & The Department of Chemistry.
We operate using a dual model: Service led or user led with training and support. Service led MS provisions are available primarily for routine accurate mass (ESI, APCI, ASAP), MALDI-MS, GC-MS and protein ID.
We also provide support, training and expertise across multiple application areas including; metabolomics, lipidomics, proteomics, native MS, intact protein analysis, quantitative- MS (with bespoke assay development), HDX-MS, DESI-MS (single point, imaging-MS and high throughput analysis) and MALDI-MS (single point and imaging-MS) and GC-MS (liquid injection/headspace; MSD & QTOF). We have a suite of instrumentation available to support this wide breadth of research.
Our separations capabilities include an established resource for HPLC and UPLC analysis with a range of detectors including DAD, RI, CAD, ELSD and fluorescence. We utilise reverse phase, HILIC, normal phase, SFC and chiral analysis. We have provisions for analytical, semi-prep and preparative scale with fraction collectors. We have provisions for GC-FID including methanizer and TCD for gas analysis and high-throughput analysis and ion chromatography.
We are a friendly team and are always happy to chat about new work and interactions with the Facility. For new internal projects please complete the following form and we will be in touch!
Mass Spectrometry & Separations @ FSE – please use the Booking/Management link
For external work please drop us an email.
We operate using a dual model: Service led or user led with training and support. Service led MS provisions are available primarily for routine accurate mass (ESI, APCI, ASAP), MALDI-MS, GC-MS and protein ID.
We also provide support, training and expertise across multiple application areas including; metabolomics, lipidomics, proteomics, native MS, intact protein analysis, quantitative- MS (with bespoke assay development), HDX-MS, DESI-MS (single point, imaging-MS and high throughput analysis) and MALDI-MS (single point and imaging-MS) and GC-MS (liquid injection/headspace; MSD & QTOF). We have a suite of instrumentation available to support this wide breadth of research.
Our separations capabilities include an established resource for HPLC and UPLC analysis with a range of detectors including DAD, RI, CAD, ELSD and fluorescence. We utilise reverse phase, HILIC, normal phase, SFC and chiral analysis. We have provisions for analytical, semi-prep and preparative scale with fraction collectors. We have provisions for GC-FID including methanizer and TCD for gas analysis and high-throughput analysis and ion chromatography.
We are a friendly team and are always happy to chat about new work and interactions with the Facility. For new internal projects please complete the following form and we will be in touch!
Mass Spectrometry & Separations @ FSE – please use the Booking/Management link
For external work please drop us an email.
Details
| Name | Mass Spectrometry and Separations Core Facility |
|---|
Keywords
- QD Chemistry
- Analytical
- TP Chemical technology
- Mass Spectrometry
- HPLC
Research technique
- Technique
Facility keywords
- Mass Spectrometry
- HPLC
Fingerprint
Explore the research areas in which this equipment has been used. These labels are generated based on the related outputs. Together they form a unique fingerprint.
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Mechanism of Photoinduced Conformational Changes in the Photoenzyme Fatty Acid Photodecarboxylase Revealed by Light- Footprinting Ion Mobility Mass Spectrometry
Meng, L., Kalapothakis, J. M. D., Ma, J., Spacey, H. J., Johannissen, L. O., Beth Alén, A., Heyes, D. J., Scrutton, N. S. & Barran, P. E., 20 May 2026, In: Journal of the American Chemical Society. 148, 19, p. 19475-19486 12 p.Research output: Contribution to journal › Article › peer-review
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Product distribution in the silicatein-catalysed synthesis of polydimethylsiloxane
Lu, Y. & Wong, L. S., 12 May 2026, In: Catalysis Science and Technology. 16, 9, p. 3183-3189 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Conformational landscapes of rigid and flexible molecules explored with variable temperature ion mobility-mass spectrometry
Wang, X., Norgate, E., Dai, J., Benoit, F., Bristow, T., England, R. M., Kalapothakis, J. M. D. & Barran, P. E., 6 May 2025, In: Nature Communications. 16, 1, 13 p., 4183.Research output: Contribution to journal › Article › peer-review