Research output per year
Research output per year
- 1 - 50 out of 274 results
Search results
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2025
Proteomic profiling of human plasma and intervertebral disc tissue reveals matrisomal, but not plasma, biomarkers of disc degeneration
Dube, C. T., Gilbert, H. T. J., Rabbitte, N., Baird, P., Patel, S., Herrera, J. A., Baricevic-Jones, I., Unwin, R. D., Chan, D., Gnanalingham, K., Hoyland, J. A. & Richardson, S. M., 10 Feb 2025, In: Arthritis Research and Therapy. 27, 28.Research output: Contribution to journal › Article › peer-review
Open Access -
2024
A novel integrated extraction protocol for multi-omic studies in heavily degraded samples
Boggi, B., Sharpen, J. D. A., Taylor, G. & Drosou, K., 30 Jul 2024, In: Scientific Reports. 14, 1, 17477.Research output: Contribution to journal › Article › peer-review
Open Access -
Complementarity of two proteomic data analysis tools in the identification of drug-metabolising enzymes and transporters in human liver
Vasilogianni, A. M., Alrubia, S., El-Khateeb, E., Al-Majdoub, Z. M., Couto, N., Achour, B., Rostami-Hodjegana, A. & Barber, J., 19 Feb 2024, In: Molecular Omics. 20, 2, p. 115-127 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Glucose influences endometrial receptivity to embryo implantation through O-GlcNAcylation-mediated regulation of the cytoskeleton
Ruane, P. T., Paterson, I., Reeves, B., Adlam, D., Berneau, S. C., Renshall, L., Brosens, J. J., Kimber, S. J., Brison, D. R., Aplin, J. D. & Westwood, M., 16 Jul 2024, In: American Journal of Physiology-Cell Physiology.Research output: Contribution to journal › Article › peer-review
Open AccessFile86 Downloads (Pure) -
Hydrogen/Deuterium Exchange-Mass Spectrometry of Integral Membrane Proteins in Native-like Environments: Current Scenario and the Way forward
Javed, W., Griffiths, D. & Politis, A., 29 Mar 2024, In: Essays in Biochemistry. 67, 2, p. 187–200Research output: Contribution to journal › Article › peer-review
Open Access -
2023
Age-Related Changes in Post-Translational Modifications of Proteins from Whole Male and Female Skeletal Elements
Johnston, E. & Buckley, M., 21 Jun 2023, In: Molecules. 28, 13, 4899.Research output: Contribution to journal › Article › peer-review
Open Access -
A Novel Blood Proteomic Signature for Prostate Cancer
Muazzam, A., Spick, M., Cexus, O. N. F., Geary, B., Azhar, F., Pandha, H., Michael, A., Reed, R., Lennon, S., Gethings, L. A., Plumb, R. S., Whetton, A. D., Geifman, N. & Townsend, P. A., 7 Feb 2023, In: Cancers. 15, 4, p. 1-17 17 p., 1051.Research output: Contribution to journal › Article › peer-review
Open Access -
A Nrf2-OSGIN1&2-HSP70 axis mediates cigarette smoke-induced endothelial detachment: Implications for plaque erosion
Satta, S., Beal, R., Smith, R., Luo, X., Ferris, G. R., Langford-Smith, A., Teasdale, J. E., Ajime, T. T., Serre, J., Hazell, G. G., Newby, G. S., Johnson, J. L., Kurinna, S., Humphries, M., Gayan-Ramirez, G., Libby, P., Degens, H., Yu, B., Johnson, T. & Alexander, Y. & 3 others, , 7 Aug 2023, In: Cardiovascular research. 119, 9, p. 1869-1882 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
A proteomics study of rheumatoid arthritis patients on etanercept identifies putative biomarkers associated with clinical outcome measures
Ling, S., Yap, C. F., Nair, N., Bluett, J., Morgan, A. W., Isaacs, J. D., Wilson, A. G., Hyrich, K., Barton, A. & Plant, D., 30 Jun 2023, In: Rheumatology.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Downloads (Pure) -
A TIAM1-TRIM28 complex mediates epigenetic silencing of protocadherins to promote migration of lung cancer cells
Ginn, L., Maltas, J., Baker, M., Chaturvedi, A., Wilson, L., Guilbert, R., Amaral, F. M. R., Priest, L., Mole, H., Blackhall, F., Diamantopoulou, Z., Somervaille, T., Hurlstone, A. & Malliri, A., 3 Oct 2023, In: Proceedings of the National Academy of Sciences. 120, 40, e2300489120.Research output: Contribution to journal › Article › peer-review
Open Access -
Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors
Gray, A. L., Karlsson, R., Roberts, A. R. E., Ridley, A. J. L., Pun, N., Khan, B., Lawless, C., Luís, R., Szpakowska, M., Chevigné, A., Hughes, C. E., Medina-Ruiz, L., Birchenough, H. L., Mulholland, I. Z., Salanga, C. L., Yates, E. A., Turnbull, J. E., Handel, T. M., Graham, G. J. & Jowitt, T. A. & 4 others, , 31 Jan 2023, In: Cell Reports. 42, 1, 111930.Research output: Contribution to journal › Article › peer-review
Open Access -
Fibrillin microfibril structure identifies long-range effects of inherited pathogenic mutations affecting a key regulatory latent TGFβ-binding site
Godwin, A., Dajani, R., Zhang, X., Thomson, J., Holmes, D., Adamo, C. S., Sengle, G., Sherratt, M., Roseman, A. & Baldock, C., 1 May 2023, In: Nature Structural and Molecular Biology. 30, p. 608–618Research output: Contribution to journal › Article › peer-review
Open Access -
Giant worm-shaped ESCRT scaffolds surround actin-independent integrin clusters
Stempels, F. C., Jiang, M., Warner, H. M., Moser, M. L., Janssens, M. H., Maassen, S., Nelen, I. H., de Boer, R., Jiemy, W. F., Knight, D., Selley, J., O’Cualain, R., Baranov, M. V., Burgers, T. C. Q., Sansevrino, R., Milovanovic, D., Heeringa, P., Jones, M. C., Vlijm, R. & Beest, M. & 1 others, , 3 Jul 2023, In: Journal of Cell Biology. 222, 7, e202205130.Research output: Contribution to journal › Article › peer-review
Open Access -
Integrating Hydrogen Deuterium Exchange-Mass Spectrometry with Molecular Simulations Enables Quantification of the Conformational Populations of the Sugar Transporter XylE
Jia, R., Bradshaw, R. T., Calvaresi, V. & Politis, A., 12 Apr 2023, In: Journal of the American Chemical Society. 145, 14, p. 7768-7779 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Loss of regulation of protein synthesis and turnover underpins an attenuated stress response in senescent human mesenchymal stem cells
Llewellyn, J., Mallikarjun, V., Appleton, E., Osipova, M., Gilbert, H. T. J., Richardson, S. M., Hubbard, S. J. & Swift, J., 4 Apr 2023, In: Proceedings of the National Academy of Sciences. 120 , 14, e2210745120.Research output: Contribution to journal › Article › peer-review
Open Access -
Lung extracellular matrix modulates KRT5+ basal cell activity in pulmonary fibrosis
Hewitt, R. J., Puttur, F., Gaboriau, D. C. A., Fercoq, F., Fresquet, M., Traves, W. J., Yates, L. L., Walker, S. A., Molyneaux, P. L., Kemp, S. V., Nicholson, A. G., Rice, A., Roberts, E., Lennon, R., Carlin, L. M., Byrne, A. J., Maher, T. M. & Lloyd, C. M., 27 Sept 2023, In: Nature Communications. 14, 1, 6039.Research output: Contribution to journal › Article › peer-review
Open Access -
Methionine Sulfoxide Reductases Suppress the Formation of the [PSI+] Prion and Protein Aggregation in Yeast
Schepers, J., Carter, Z., Kritsiligkou, P. & Grant, C. M., 7 Feb 2023, In: Antioxidants. 12, 2, 401.Research output: Contribution to journal › Article › peer-review
Open Access -
Mmp14 is required for matrisome homeostasis and circadian rhythm in fibroblasts
Yeung, C.-Y. C., Garva, R., Pickard, A., Lu, Y., Mallikarjun, V., Swift, J., Taylor, S. H., Rai, J., Eyre, D. R., Chaturvedi, M., Itoh, Y., Meng, Q.-J., Mauch, C., Zigrino, P. & Kadler, K. E., 1 Dec 2023, In: Matrix biology : journal of the International Society for Matrix Biology. 124, p. 8-22 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Modeling collagen fibril self-assembly from extracellular medium in embryonic tendon
Revell, C. K., Herrera, J. A., Lawless, C., Lu, Y., Kadler, K. E., Chang, J. & Jensen, O. E., 22 Aug 2023, In: Biophysical Journal. 122, 16, p. 3219-3237 19 p.Research output: Contribution to journal › Article › peer-review
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Morphologically intact airways in lung fibrosis have an abnormal proteome
Herrera, J. A., Dingle, L. A., Monetero, M. A., Venkateswaran, R. V., Blaikley, J. F., Granato, F., Pearson, S., Lawless, C. & Thornton, D. J., 1 Apr 2023, In: Respiratory Research. 24, 1, 99.Research output: Contribution to journal › Article › peer-review
Open Access -
Multi-regional alterations in glucose and purine metabolic pathways in the Parkinson’s disease dementia brain
Scholefield, M., Church, S., Taylor, G., Knight, D., Unwin, R. & Cooper, G., 20 Apr 2023, In: npj Parkinson's Disease. 9, 1, 66.Research output: Contribution to journal › Article › peer-review
Open Access -
Oncogenic ERRB2 signals through the AP-1 transcription factor to control mesenchymal-like properties of oesophageal adenocarcinoma
Ogden, S., Ahmed, I., Yang, S.-H., Fullwood, P., Francavilla, C. & Sharrocks, A. D., 1 Mar 2023, In: NAR cancer. 5, 1, zcad001.Research output: Contribution to journal › Article › peer-review
Open Access -
Paralogous translation factors target distinct mRNAs to differentially regulate tolerance to oxidative stress in yeast
Cunningham, J., Sfakianos, A., Kritsiligkou, P., Kershaw, C. J., Whitmarsh, A., Hubbard, S., Ashe, M. & Grant, C., 8 Sept 2023, In: Nucleic acids research. 51, 16, p. 8820–8835Research output: Contribution to journal › Article › peer-review
Open Access -
Peptide location fingerprinting identifies structural alterations within basement membrane components in ageing kidney
Eckersley, A. (Lead), Paiva Teixeira Morais, M., Ozols, M. & Lennon, R. (Corresponding), Aug 2023, In: Matrix Biology. 121, p. 167-178 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Proteomic analysis identifies subgroups of patients with active systemic lupus erythematosus
MASTERPLANS Consortium & BILAG-BR consortia, 29 Jul 2023, In: Clinical Proteomics. 20, 1, 17 p., 29.Research output: Contribution to journal › Article › peer-review
Open Access -
Proteomic quantification of receptor tyrosine kinases involved in the development and progression of colorectal cancer liver metastasis
Vasilogianni, A.-M., Al-Majdoub, Z. M., Achour, B., Peters, S. A., Rostami-Hodjegan, A. & Barber, J., 20 Feb 2023, In: Frontiers in Oncology. 13, 1010563.Research output: Contribution to journal › Article › peer-review
Open Access -
Proteomic signature associated with chronic kidney disease (CKD) progression identified by data-independent acquisition mass spectrometry
Ramírez Medina, C. R., Ali, I., Baricevic-Jones, I., Odudu, A., Saleem, M. A., Whetton, A. D., Kalra, P. A. & Geifman, N., 20 Apr 2023, In: Clinical Proteomics. 20, 1, 19.Research output: Contribution to journal › Article › peer-review
Open Access -
Protocol to characterize basement membranes during kidney development using mass spectrometry-based label-free quantitative proteomics
Morais, M. R. P. T., Tian, P., O'cualain, R., Lawless, C. & Lennon, R., 15 Dec 2023, In: STAR protocols. 4, 4, 102741.Research output: Contribution to journal › Article › peer-review
Open Access -
Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families
Wilson, B., Flett, C., Gemperle, J., Lawless, C., Hartshorn, M., Hinde, E., Harrison, T., Chastney, M., Taylor, S., Allen, J., Norman, J. C., Zacharchenko, T. & Caswell, P. T., 15 Jun 2023, In: Journal of Cell Science. 136, 12Research output: Contribution to journal › Article › peer-review
Open Access -
Quantitative SWATH-based proteomic profiling of urine for the identification of endometrial cancer biomarkers in symptomatic women
Njoku, K., Pierce, A., Geary, B., Campbell, A. E., Kelsall, J., Reed, R., Armit, A., Da sylva, R., Zhang, L., Agnew, H., Baricevic-Jones, I., Chiasserini, D., Whetton, A. D. & Crosbie, E. J., 17 Feb 2023, (E-pub ahead of print) In: British Journal of Cancer.Research output: Contribution to journal › Article › peer-review
Open Access -
Restored autophagy is protective against PAK3-induced cardiac dysfunction
Ruiz Velasco Hernandez, A., Raja, R., Chen, X., Ganenthiran, H., Kaur, N., Alatawi, N. H. O., Miller, J. M., Abouleisa, R. R. E., Ou, Q., Zhao, X., Fonseka, O., Wang, X., Hille, S., Frey, N., Wang, T., Mohamed, T., Müller, O. J., Cartwright, E. & Liu, W., 16 Jun 2023, In: iScience. 26, 6, 106970.Research output: Contribution to journal › Article › peer-review
Open Access -
Systemically administered wound-homing peptide accelerates wound healing by modulating syndecan-4 function
Maldonado, H., Savage, B. D., Barker, H. R., May, U., Vähätupa, M., Badiani, R. K., Wolanska, K. I., Turner, C. M. L., Pemmari, T., Ketomäki, T., Prince, S., Humphries, M., Ruoslahti, E., Morgan, M. R. & Järvinen, T. A. H., 6 Dec 2023, In: Nature Communications. 14, 1, 8069.Research output: Contribution to journal › Article › peer-review
Open Access -
The circadian clock and extracellular matrix homeostasis in ageing and age-related diseases
Dudek, M., Swift, J. & Meng, Q.-J., 29 May 2023, (E-pub ahead of print) In: American Journal of Physiology-Cell Physiology.Research output: Contribution to journal › Article › peer-review
Open AccessFile283 Downloads (Pure) -
The interplay between Cs and K in Pseudanabaena catenata; from microbial bloom control strategies to bioremediation options for radioactive waters
Zhang, K., Foster, L., Buchanan, D., Coker, V. S., Pittman, J. K. & Lloyd, J. R., 5 Mar 2023, In: Journal of Hazardous Materials. 445, 130556.Research output: Contribution to journal › Article › peer-review
Open Access -
Toward systems-informed models for biologics disposition: covariates of the abundance of the neonatal Fc Receptor (FcRn) in human tissues and implications for pharmacokinetic modelling
Barber, J., Al-Majdoub, Z. M., Couto, N., Howard, M., Elmorsi, Y., Scotcher, D., Alizai, N., de Wildt, S., Stader, F., Sepp, A., Rostami-Hodjegan, A. & Achour, B., 1 Mar 2023, In: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 182, p. 106375Research output: Contribution to journal › Article › peer-review
Open Access -
Vimentin intermediate filaments provide structural stability to the mammalian Golgi complex
Vitali, T., Sanchez-Alvarez, R., Witkos, T. M., Bantounas, I., Cutiongco, M. F. A., Dudek, M., Yan, G., Mironov, A. A., Swift, J. & Lowe, M., 18 Oct 2023, In: Journal of Cell Science. 136, 20, jcs260577.Research output: Contribution to journal › Article › peer-review
Open Access -
Widespread Selenium Deficiency in the Brain of Cases with Huntington’s Disease Presents a New Potential Therapeutic Target
Scholefield, M., Patassini, S., Xu, J. & Cooper, G. J. S., 1 Nov 2023, In: EBioMedicine. 97, 104824.Research output: Contribution to journal › Article › peer-review
Open Access -
ZMYM2 controls human transposable element transcription through distinct co-regulatory complexes
Owen, D. J., Aguilar-Martinez, E., Ji, Z., Li, Y. & Sharrocks, A. D., 7 Nov 2023, In: eLife. 12, RP86669.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids
Below, C., Kelly, J., Brown, A., Humphries, J., Hutton, C., Xu, J., Lee, B., Cintas, C., Zhang, X., Hernandez-Gordillo, V., Stockdale, L., Goldsworthy, M., Geraghty, J., Foster, L., O'Reilly, D., Schedding, B., Askari, J., Burns, J., Hodson, N. & Smith, D. & 10 others, , 1 Jan 2022, In: Nature Materials. 21, 1, p. 110-119 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Amino acid availability acts as a metabolic rheostat to determine the magnitude of ILC2 responses
Hodge, S., Zancanaro Krauss, M. E., Kaymak, I., King, J., Howden, A. J. M., Panic, G., Grencis, R., Swann, J., Sinclair, L. V. & Hepworth, M., 26 Dec 2022, In: Journal of Experimental Medicine.Research output: Contribution to journal › Article › peer-review
Open Access -
Clinical implications of altered drug transporter abundance/function and PBPK modeling in specific populations: An ITC perspective
Chu, X., Prasad, B., Neuhoff, S., Yoshida, K., Leeder, J. S., Mukherjee, D., Taskar, K., Varma, M. V., Zhang, X., Yang, X. & Galetin, A., 13 May 2022, (E-pub ahead of print) In: Clinical Pharmacology & Therapeutics.Research output: Contribution to journal › Article › peer-review
Open AccessFile399 Downloads (Pure) -
Coenzyme A-Dependent Tricarboxylic Acid Cycle Enzymes Are Decreased in Alzheimer’s Disease Consistent With Cerebral Pantothenate Deficiency
Sang, C., Philbert, S., Hartland, D., Unwin, R., Dowsey, A., Xu, J. & Cooper, G. J., 10 Jun 2022, In: Frontiers in aging neuroscience. 14, 893159, p. 893159 893159.Research output: Contribution to journal › Article › peer-review
Open Access -
Collagen fingerprinting of Caribbean archaeological fish bones: Methodological implications for historical fisheries baselines and anthropogenic change
Harvey, V. L., Lefebvre, M. J., Sharpe, A. E., Toftgaard, C., Defrance, S. D., Giovas, C. M., Fitzpatrick, S. M. & Buckley, M., 1 Sept 2022, In: Journal of Archaeological Science. 145, 105642.Research output: Contribution to journal › Article › peer-review
Open AccessFile97 Downloads (Pure) -
Contrasting Sodium and Potassium Perturbations in the Hippocampus Indicate Potential Na +/K +-ATPase Dysfunction in Vascular Dementia
Philbert, S., Cooper, G. J., Xu, J., Unwin, R., Church, S. & Scholefield, M., 28 Jan 2022, In: Frontiers in aging neuroscience. 14, p. 822787 822787.Research output: Contribution to journal › Article › peer-review
Open Access -
Cytosolic aspartate aminotransferase moonlights as a ribosome binding modulator of Gcn2 activity during oxidative stress
Crawford, R. A., Ashe, M. P., Hubbard, S. J. & Pavitt, G. D., 13 Jun 2022, In: eLife. 11, e73466.Research output: Contribution to journal › Article › peer-review
Open Access -
Elevated hippocampal copper in cases of type 2 diabetes
Philbert, S., Schönberger, S., Xu, J., Church, S., Unwin, R. & Cooper, G. J., 1 Dec 2022, In: EBioMedicine. 86, 104317, 104317.Research output: Contribution to journal › Article › peer-review
Open Access -
Excess S-Adenosylmethionine inhibits methylation via catabolism to adenine
Fukumoto, K., Ito, K., Saer, B., Taylor, G., Ye, S., Yamano, M., Toriba, Y., Hayes, A., Okamura, H. & Fustin, J.-M., 5 Apr 2022, In: Communications Biology. 5, 1, p. 1-15 15 p., 313.Research output: Contribution to journal › Article › peer-review
Open Access -
Kidney organoids recapitulate human basement membrane assembly in health and disease
Morais, M. R., Tian, P., Lawless, C., Murtuza-baker, S., Hopkinson, L., Woods, S., Mironov, A., Long, D. A., Gale, D. P., Zorn, T. M., Kimber, S. J., Zent, R. & Lennon, R., 25 Jan 2022, In: eLife. 11Research output: Contribution to journal › Article › peer-review
Open Access -
Levels of soluble complement regulators predict severity of COVID-19 symptoms
Tierney, A. L., Alali, W. M., Scott, T., Rees-Unwin, K. S., Clark, S. J., CITIID-NIHR BioResource COVID-19 Collaboration & Unwin, R. D., 18 Oct 2022, In: Frontiers in Immunology. 13, 1032331.Research output: Contribution to journal › Article › peer-review
Open Access -
Medieval fish remains on the Newport ship identified by ZooMS collagen peptide mass fingerprinting
Buckley, M., Harvey, V. L., Petiffer, D., Russ, H., Wouters, W. & Van Neer, W., 1 Mar 2022, In: Archaeological and Anthropological Sciences. 14, 3, 41.Research output: Contribution to journal › Article › peer-review
Open Access