Research output per year
Research output per year
Personal profile
Overview
My research focuses on embryo-endometrial interactions during human embryo implantation. I came from a cell biology background before embarking on post-doctoral studies to investigate implantation. In 2018, I began a Fellowship at the Maternal and Fetal Research Centre to develop and interrogate sophisticated in vitro models of human embryo implantation and placenta using embryos and stem/primary cell systems. Cell biology techniques, microscopy and in silico integration of omics data are being leveraged to understand the basic biology of implantation and placentation. Particular focus is being trained on how defective implantation contributes to infertility and pregnancy complications. Mouse models are also utilised to investigate how events at implantation can lead to developmental programming effects on offspring health.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, Functional Characterisation of the Microtubule Plus End-Associated EB Protein Family Member, EB2, University of Leeds
1 Sept 2006 → 31 Aug 2010
Award Date: 15 Mar 2011
Bachelor of Science, Cell Biology with Industrial Experience, The University of Manchester
Sept 2002 → Jun 2006
Award Date: 1 Jul 2006
External positions
Associate Editor, Human Reproduction, European Society for Human Reproduction & Embryology (ESHRE)
1 Dec 2018 → …
Areas of expertise
- QH301 Biology
- embryo implantation
- trophoblast
- endometrium
- embryology
- developmental programming
- cell biology
- systems biology
- developmental biology
- placenta
Research Beacons, Institutes and Platforms
- Lydia Becker Institute
- Healthier Futures
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Embryo-epithelium interactions during implantation at a glance
Aplin, J. D. & Ruane, P. T., 2017, In: Journal of Cell Science. 130, 1, p. 15-22 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile505 Downloads (Pure) -
The effects of hyaluronate-containing medium on human embryo attachment to endometrial epithelial cells in vitro
Ruane, P. T., Buck, C. J., Babbington, P. A., Aboussahoud, W., Berneau, S. C., Westwood, M., Kimber, S. J., Aplin, J. D. & Brison, D. R., Feb 2020, In: Human Reproduction Open. 2020, 2Research output: Contribution to journal › Article › peer-review
Open Access -
Apposition to endometrial epithelial cells activates mouse blastocysts for implantation
Ruane, P., Berneau, S., Koeck, R., Kimber, S., Brison, D., Westwood, M. & Aplin, J., Sept 2017, In: Molecular Human Reproduction. 23, 9, p. 617-627 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile195 Downloads (Pure) -
Glucose influences endometrial receptivity to embryo implantation through O-GlcNAcylation-mediated regulation of the cytoskeleton
Ruane, P. T., Paterson, I., Reeves, B., Adlam, D., Berneau, S. C., Renshall, L., Brosens, J. J., Kimber, S. J., Brison, D. R., Aplin, J. D. & Westwood, M., 16 Jul 2024, In: American Journal of Physiology-Cell Physiology.Research output: Contribution to journal › Article › peer-review
Open AccessFile39 Downloads (Pure) -
A systematic review of transcriptomic studies of the human endometrium reveals inconsistently reported differentially expressed genes
Walker, E. R., McGrane, M., Aplin, J. D., Brison, D. R. & Ruane, P. T., 7 Jul 2023, In: Reproduction and Fertility. 4, 3, e220115.Research output: Contribution to journal › Article › peer-review
Open Access
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Maternal & Fetal Health Research Centre
Stevens, A. (PI), Heazell, A. (PI), Tower, C. (PI), Brison, D. (PI), Johnstone, E. (PI), Cottrell, E. (PI), Mann, E. (PI), Ingram, E. (PI), Crocker, I. (PI), Chernyavsky, I. (PI), Myers, J. (PI), Aplin, J. (PI), Higgins, L. (PI), Harris, L. (PI), Dilworth, M. (PI), Westwood, M. (PI), Whitworth, M. (PI), Desforges, M. (PI), Brownbill, P. (PI), Ruane, P. (PI), Sturmey, R. (PI), Worton, S. (PI), Greenwood, S. (PI) & Sibley, C. (PI)
1/09/18 → 31/12/35
Project: Research
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Tommy's 2024-2025 Annual Budget
Heazell, A. (PI), Aplin, J. (CoI), Brownbill, P. (CoI), Cottrell, E. (CoI), Desforges, M. (CoI), Dilworth, M. (CoI), Higgins, L. (CoI), Johnstone, E. (CoI), Myers, J. (CoI), Palin, V. (CoI), Ruane, P. (CoI), Stevens, A. (CoI), Tropea, T. (CoI), Westwood, M. (CoI) & Worton, S. (CoI)
1/04/24 → 31/03/25
Project: Research
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Relating Environment-use Scenarios in Pregnancy/Infanthood and Resulting airborne-material Exposures to child-health outcomes (RESPIRE)
Johnstone, E. (PI), Povey, A. (CoI), Van Tongeren, M. (CoI), Ruane, P. (CoI), Bannan, T. (CoI), Gittins, M. (CoI) & Higgins, L. (CoI)
1/11/21 → 31/10/25
Project: Research
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Periconceptional Programming of Health Training Network.
Brison, D. (PI), Clayton, P. (CoI), Roberts, S. (CoI), Stevens, A. (CoI) & Ruane, P. (Grant contributor)
1/07/19 → 30/11/23
Project: Research